300-Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, & more
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February 23, 2026
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In this episode, we discuss:
0:00:35 – Defining the categories of “proven, promising, fuzzy, noise, and nonsense”
0:07:35 – Rapamycin
0:16:15 – Metformin
0:24:35 – NAD and its precursors
0:34:21 – Resveratrol
0:40:40 – The importance of VO2 max, muscle mass, and muscular strength for lifespan
0:47:02 – Blood flow restriction (BFR) training
0:55:11 – Using stem cells to treat osteoarthritis or injury
1:00:44 – Fasting as a tool for longevity (and why Peter stopped his fasting protocol)
1:12:55 – The energy balance theory
1:19:29 – The idea that sugar is poison
1:31:38 – The idea that sugar substitutes are dangerous
1:39:10 – The debate on red meat and cancer
Peter, cows that eat corn are inflamed
Not that sure about BFR and strength. Protocols for BFR are usually done with shorter rest. If you compare group A on BFR with 30sec-45sec rest vs group B no BFR and 2 mins rest, which group would be able to produce more strength? My money is on group B. BFR is time efficient and I think the literature is pretty solid for hypertrophy, but not for strength, otherwise everybody in powerlifting would do BFR protocols and its just not the case. If both groups did 20 reps with 15 pounds DB curl, OF COURSE group A (on BFR) would produce more strength because each set was closer to failure. I dont think strength gains are superior when volume AND effort is equated between BFR group vs non BFR group.
ABSOLUTELY FANTASTIC.
This podcast is very helpful! Thank you for sharing!
Sugar isn't a poison, no one died from eating sugar. People die from eating too much sugar.
I think your a pretty rationale guy. I would say that if the body mechanic are well understood that a nutrition trials shouldn't be a reason to not recommend a change in diet. If you can show harm thats enough not to do. If you can't show harm don't tell me not to do. I also like the dose dependency and would add in the consideration of where a person is at metabolically. If one is very metabolically ill, sugar may be a poison for them.
Second of these I have watched. Peter is great! Clear! Articulate! The other guy sounds like he is in a drug induced foggy haze. PLEASE PLEASE speak up! Stop mumbling and whispering like you are in A Quiet Place!!!!!!
The bearded muppet's NPR voice has me suicidal.
I like the summary synthesis videos!!!❤
And these are helpful to most people, I think.
Rampanicin seems to be the most startling chapter in the video.
why i found that the bacteria in rapamycin might cause cancer? "Sirolimus may increase the risk that you will develop an infection or cancer, especially lymphoma (cancer of a part of the immune system) or skin cancer." https://medlineplus.gov/druginfo/meds/a602026.html
+1 Loved the format! Thank you.
One thousand million percent love this style of breakdown. Holy holy cow – this is so fundamentally helpful at so many levels – especially for those of us (me) that are constantly short on time but can take an hour plus periodically and take in a bullet style summary of the things you/research/data/science have uncovered about health, fitness, longevity, wellness, nutrition, etc. etc. etc. Love every bit of it.
DON’T DO DRUGS !!!!! GOOD GOD! ARE YOU GUYS CRAZY?
Who is the moron?
This podcast format is a winner!
Peter, congratulations on the success of your book and podcast- both of which I find to be the very best. One thing, I hope you change your mind on the role of dietitians as you make your way through the next 100 episodes. I agree that it's challenging offering nutrition recommendations in a field that is often driven by dodgy science. Discernment is key and I appreciate your help sorting through the "fuzz and noise". Best of luck as your next 100 episodes unfold.
Exercise is bound to improve lifespan. Recovery from serious accidents is faster/more complete for those in ""atheletic" condition (extrapolation)… which should be enough to motivate you anyway😂
1:02:42 fuzzy? bro we have the data on iso-caloric outcomes …
ABSOLUTELY more of this ranking !!! ❤😊
Would love Dr Attia to discuss zone 2 and effects on left ventricular ejection fraction for healthy and heart failure cases.
I thoroughly enjoyed hearing your insights. Absolutely brilliant and I appreciate the man who interviewed you ❤️
Very helpful thank you 🙏🏻