303-A breakthrough in Alzheimer’s disease: potential of klotho for brain health & as a therapeutic
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"Harmony in Every Heartbeat
In this episode, we discuss:
0:01:19 – Dena’s fascination with aging and how she came to study klotho
0:11:00 – Biological properties of klotho: production, regulation, decline with age, and factors influencing its levels
0:23:08 – Potential benefits of klotho on brain health
0:36:18 – The relationship between soluble klotho protein, platelet factors, and cognitive enhancement
0:52:31 – The role of platelet factor 4 (PF4) and it’s interaction with GluN2B in mediating cognitive enhancement
1:02:52 – Benefits of klotho observed in a mouse model of Parkinson’s disease
1:11:22 – Benefits of klotho observed in a mouse model of Alzheimer’s disease
1:17:18 – Promising results of klotho in primate models, and the importance of finding an appropriate therapeutic dose before moving to human trials
1:39:34 – Speculating why a single klotho injection has such long-lasting effects
1:42:45 – Potential cognitive benefits of klotho in humans, the impact of the KL-VS genetic variant on klotho levels, and the need for human trials to confirm these effects
1:50:10 – The interaction between the KL-VS genetic variant and APOE4 and how it impacts risk of Alzheimer’s disease
2:05:26 – The significance of klotho levels: studies linking lower levels to increased mortality and the broader implications for organ health and disease prevention
2:11:48 – Measuring klotho levels and determining an individual’s KL-VS status
2:18:32 – The promising potential of klotho for Alzheimer’s disease treatment, and the importance of philanthropy for funding research
Would love to be part of human trials.
what about TRONTINEMAB
I have one copy of the APOE4 variant (APOE3/4) Alzheimer's Gene but thankfully I also have one copy of the klotho-vs allele which reduces the impact of my APOE4 variant by 75%. I feel lucky!!
Why wait? I have been taking Klotho protein subq for a few years now. Works great for anti-aging
Is this a coya theraputics trial?
As to the long term effects per dose, it sounds akin to how a single psychedelic dose can remodel neurons and last months.
Also what about possible gut brain effects via the vagus nerve to effect the brain from periphery?
Fascinating listen! I look forward to hearing more from her and her colleagues on this worthwhile topic. Meanwhile, we must continue to pursue and promote the healthy lifestyle habits.
Thanks to Peter I developed an incredibly healthy lifestyle but also a big fear of neurodegenerative illnesses.
This episode gives me hope there might be some medication for Alzheimers in the future!
Fascinating!
Intellix DNA does provide information on SNP’s for Klotho.
Mice are "People"…………..if you accept that, this research is a Holocaust
Absolutely fascinating.
How exciting! Looking forward to hearing more as Scientists further progress this research.
1st section of 'The Three Fates ' on ELP's 1st album entitled 'Clotho'!
https://www.youtube.com/watch?v=vQjvBD21peI&ab_channel=Emerson%2CLakeandPalmer
ADAMTS antibodies are related to TTP
So it doesn’t surprise me that platelets were involved in this area of metabolism
I realize that that there are dozens of ADAMTS factors
Im not sure why she would be surprised that platelets are involved. It’s fundamental in internal medicine teaching for the last 50 years
I’m happy to be wrong, it just seems very obvious for even me, a person with very much less bona fides in the area
thank you very interesting
25:58
Am I wrong in understanding the meaning of the word “facile”?
I thought it meant an only superficial understanding
Maybe Dr. Attia misspoke and meant another word?
The different understandings of a mouse’s daily metabolism seems to be a huge point to me, I could be wrong about that as well
Loved the podcast!
There is no letter C in the Greek alphabet. Only K for the k sound
We need to develop a Cognitive Panel. Getting labs CBC, Chem 24, Lipid Panel and a COGNITIVE PANEL.
Thank you for your videos Peter your work is more valuable than money.Some of the comments makes me think people didn't watch it or came to bash because they're part of the new anti-science ilk.