283 ‒ Gut health & the microbiome: improving and maintaining the microbiome, probiotics, & more
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March 20, 2025
In this episode, we discuss:
0:00:34 – Colleen’s background and current focus
0:03:08 – The basics of the microbiome
0:12:37 – The study of the human microbiome
0:17:42 – Categories of bacteria, and the implications on health of the rapid evolution of bacteria
0:27:51 – Methods for measuring and understanding the microbiome, and key indicators of microbiome health
0:39:52 – The important role of fiber for promoting gut health through the production of butyrate
0:47:21 – The case for manipulating gut bacteria via fecal microbiota transplant (FMT)
0:53:25 – Dynamics of the microbiome: the gut-brain connection and how antibiotics, nutrition, stress, and more impact the microbiome's diversity and function
0:59:16 – Factors that influence the vaginal microbiome
1:03:46 – The effect of gut microbes on obesity and challenges with fecal transplants in people
1:06:25 – Beneficial strains of gut bacteria and strains commonly found in probiotics
1:16:35 – The difference between a probiotic and prebiotic, and how CFUs are a measure of the “active ingredient”
1:21:47 – Considerations about how probiotic strains are produced, and more on the meaning of CFU
1:31:12 – Mitigating the effect of antibiotics on the microbiome
1:39:58 – What do we know about the effect of artificial sweeteners on the gut microbiome?
1:47:02 – Why Akkermansia is a keystone strain with implications for metabolic health and an individual’s response to dietary interventions
1:58:14 – The essential steps necessary to develop a robust probiotic for optimal health support
2:01:45 – How Akkermansia helps control blood glucose, and potential implications of Akkermansia in weight loss, diabetes management, and more
2:22:46 – Pendulum Therapeutics’ commitment to rigorous product develop
2:29:54 – Details about the probiotic “Glucose Control” and other probiotics developed by Pendulum Therapeutics
2:38:43 – Further studies of Akkermansia that have been proposed or are underway
I came down with a massive immune response that modern medicine couldn’t figure out and was continually told we can’t find anything wrong with you. So I did a fecal transplant in my kitchen and shut down my autoimmune response. The doctors were amazed and shocked at what I had done. Still very healthy two years later.
Excellent, fascinating, highly professional episode and discussion.
Thank you so much !!
This seems like a conversation by doctors, for doctors, versus practical advice for the rest of us
I'm sorry, Attia presents great concepts, but spoils it with interrupting, being humorless and being a smarty pants 😢. Ugh
Hey Peter, first of all great book! My question is could a fecal microbiome transplant help people with their obesity issues? What would this do, could it reduce or eliminate sugar cravings assuming that the fecal sample is from a healthy microbiome?
21:19 "Mouth to anus " count 4 and I'm just 20 minutes into the video.
There is no reason to ever pick up a Diet Coke . A coke at that
Will your prebiotic help treat hpylori
It's mutable – programmer
@11:11 – No, we don't have C. Difficile anymore. It's one of many they intentionally wiped out with antibiotics and won't return to us.
That's my valid opinion and based on fact – do research on how many are wiped out in most of us. You'd be suprised. They do in it sneaky sneaky ways.
What’s the deal with repeating mouth to anus a million times ? It’s gross and not even true.
No, your *esophagus* is not part of the *guts* (or *intestines**), but it is part of the **digestive system**. The esophagus is a muscular tube that connects the **throat* (pharynx) to the *stomach* and serves as the pathway for food and liquids. It’s located in the upper portion of the digestive tract, while the "guts" or intestines are lower in the digestive system and include the *small intestine* and **large intestine**.
Here’s a quick breakdown:
– **Esophagus**: Transports food and liquids from the mouth to the stomach.
– *Guts (Intestines)**: Primarily responsible for digestion and absorption of nutrients, as well as waste elimination, and consist of the **small intestine* and **large intestine**.
So, while the esophagus plays a crucial role in digestion, it’s anatomically distinct from the "guts."
This is a great interview. Lots of detail. Second time I've watched it. I'm almost 3 months into GLP 1 probiotic. Most notable is getting full faster and some sugar craving reduction. I'll continue on for 6 more months to see if I can get additional benefits. I don't think it's a magic pill. I try to increase daily fibre to maximize benefits. Would love to see an interview with a researcher at Stanford microbiology and immunology lab. Thanks!
Should a normal healthy person take Akkermansia supplements and if so, how much for how long? Ty
I love Peter demeanor, so respectful knowledgeable, great guests, all for free!!!
Anything got microbiome, im in!!
Good luck 🍀 Peter I hope you continue to do well.
Gut is life, nothing else
Gut is so important, so we call gut feeling
Life is what out gut is
We must feed good microbes and make fast for bad microbes
Our health depends on gut microbes ecosystem
How to boost Akkermansia naturally?
Akkermansia feeds and grows on onions, garlic, leeks, artichoke, yams, agave, bananas, Brussel sprouts, okra, cauliflower, broccoli, chicory root. You can boost your levels of akkermansia by eating polyphenol-rich foods, and by fasting (as they feed off your mucus, not your food!).
What prebiotics feed Akkermansia?
Berberine is a potent prebiotic for Akkermansia. Berberine promotes Akkermansia growth via stimulating mucin secretion in host intestine. The research puts forward a novel insight into the modulation of functional gut microbes.
I am learning a lot of basics here. Gosh it’s so important!
I have started taking Akkermansia a month ago before watching this video (today) and I have some distinct measurable outcomes. Good or bad I don’t know.
1. I am an OMAD and normally I will have a meal at breakfast and that is it. By night time I start to feel hungry and I go to bed hungry which gives me a good sleep and I wake up and have a meal again. But since I have started taking Akkermansia I do not even feel hungry at night time anymore and sometimes the next morning I feel like am not hungry but I eat anyway.
2. It feels like the gut motility has really slowed down.
I don’t know this is an overall good or bad thing. I haven’t done any blood tests etc. not that they will reveal anything as my metabolic markers are one of the best one can desire but if you ask me I will rather be on my earlier state than this so I am thinking of discontinue it. But some people might benefit from it if it makes them less hungry and more full.
In regards to fecal therapy to replenish someone’s Microbiome post antibiotics, is it possible to take that person’s fecal before the antibiotics so they stay the same as before?
Sun exposure effects Microbiom
So informative I’m so glad to have access to this. I am so blessed and grateful.
Why do I feel so much better on carnivore diet? I follow Metabolic Mind. I don’t eat fibre at all. Better mentally and physically.
Lewis William Rodriguez Kevin Jones Anna
Perez Joseph Moore Jessica Robinson Jeffrey
But doesn’t the acid in your stomach destroy all of these things before they can do anything
As usual another episode full of amazing information. As someone who is recently new to the gut microbiome I have made my first purchase to pendulum products. Out of curiosity, would using a capsule once a week as a suppository result in a better lower GI population than having it go through the stomach acid?
As a side note, if yourself or Andrew Huberman ever make a crapsul I will be first on the list to try it😂
uuuuuhhh it has been said that humans are the virus on this planet and are now living in 'captivity'
Thanks very good but34 minutes listening and can’t get anything related to lay ordinary lay people not medical doctors who have no time to listen to such podcasts. Podcasts better if teach practical doable natural cost effective means and tools .
humans are living in a symbiosis with bacteria?
Should we allow kids to play with poo?
Whats in it for the bacteria? We need them to break down nutrients, what do they get out of it?
My bio dome is ever expanding
The food I eat is micro
World I see macro
Grains of sand particles of this world
Ions of water carry the fiber of organisms
Evolvement of magnetic attraction
Manifesting all I see
Miracle is what I see
Bio Dome
Cosmic reflection
Our existence is a projection of our cellular development
The cycle of ingestion and
representation of our selections
Alton
Ah she was explaining the shotgun meta sequencing and then the different testing and you kept interrupting her so many times that the conversation went elsewhere… …. And also there is no way to accurately determine health effects because there is an entire group of organisms that has not been analyzed…. Parasites… the helminths.. I think it’s a waste of time to try to look at the effects of bacteria, fungi and viruses…. Because the parasites have been ignored…. All the data is unreliable bc the parasites have not been sequenced and analyzed in the same way that bacteria fungi have using the 16s…
please do a podcast on the parkinson gut with its inflamation and how to reduce it?
both of you were excellent!!! please look into your new strains to help advanced parkinson . the more i doctor google ,the more i believe is if you can fix the gut first it will help millons of people that help live a better life. i am starting to think it would help start the ball rolling. i do hear some pd doctors talk about glp-1 was going to help in the near future. please work on this. neuralli has started the ball roiling with ps128. L plantarum .
As if we couldn't understand how people's got fat or y & all these health problems have arised with wt gain , like oop's & oh no ! 💝🚴 y u exercise, its fun & good for us , like wee weee fun , varoom fast so much fun & u burn off your food ! 💝😎